Description

4-[3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl]Aniline is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylated indazole-aniline hybrid structure. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the indazole core.
• Material Science: Serves as a monomer or functional additive in the research of advanced polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation and the development of chemical tools for biological studies.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthetic chemistry.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl]Aniline
CAS No.	353457-63-3
Molecular Formula	C14H14F3N3
Molecular Weight	281.28 g/mol
Synonyms	1-(4-Aminophenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole; 4-[3-(Trifluoromethyl)-4,5,6,7-tetrahydro-2H-indazol-1-yl]aniline; 4-(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)aniline; 353457-63-3; 4-(3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzenamine; Aniline, 4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-
EINECS	Contact for details

Quality Control

Our 4-[3-(Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazol-1-Yl]Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.