Description

1-(4-Bromo-2-Fluorophenyl)Ethanol is a versatile fluorinated and brominated aromatic alcohol building block. This compound matters for its unique bifunctional halogenated structure, which is critical for introducing specific steric and electronic properties into target molecules. It is primarily needed by pharmaceutical, agrochemical, and advanced material research and development sectors for synthesizing active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chiral Resolution Studies: The chiral center allows for use in developing and testing methods for enantiomeric separation and asymmetric synthesis.
• Polymer Modification: Employed to introduce halogenated phenyl groups into polymer chains, altering physical properties like refractive index and thermal stability.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)Ethanol
CAS No.	353282-88-9
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	(4-Bromo-2-fluorophenyl)methyl carbinol; 1-(4-Bromo-2-fluorophenyl)ethan-1-ol; α-Methyl-4-bromo-2-fluorobenzyl alcohol; 2-Fluoro-4-bromophenethyl alcohol (related); 4-Bromo-2-fluoro-α-methylbenzenemethanol; 1-(4-Bromo-2-fluorophenyl)ethyl alcohol; CAS 353282-88-9
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2-Fluorophenyl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.