Description

2-(n-Morpholino)Ethanesulfonic Acid-D13 is a deuterated isotopologue of the widely used MES buffer, where thirteen hydrogen atoms are replaced with deuterium. This high-purity labeled compound is essential for applications requiring minimal spectral interference and enhanced stability in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). It is primarily utilized by researchers and manufacturers in pharmaceutical development, analytical chemistry, and metabolic studies where precise isotopic tracing is critical.

Application

• Internal Standard for Quantitative Analysis: Serves as a stable, non-interfering internal standard in LC-MS and GC-MS for the accurate quantification of MES and related compounds.
• NMR Spectroscopy Solvent & Buffer: Provides a deuterated buffer component for NMR studies, reducing proton background signals and enabling clearer structural analysis of biological molecules.
• Metabolic Pathway Tracing: Used in deuterium labeling experiments to track biochemical pathways and drug metabolism in pharmaceutical research.
• Biochemical & Pharmaceutical Research: Acts as a buffering agent in deuterated media for studying enzyme kinetics, protein stability, and formulation science under isotopically controlled conditions.
• Production of Labeled Compounds: A key synthetic intermediate or starting material for preparing other deuterium-labeled fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-(n-Morpholino)Ethanesulfonic Acid-D13
CAS No.	352534-94-2
Molecular Formula	C6D13NO4S
Molecular Weight	219.30 g/mol
Synonyms	MES-d13; 2-(N-Morpholino)ethanesulfonic Acid-d13; Deuterated MES; 4-Morpholineethanesulfonic Acid-d13; 2-Morpholinoethanesulfonic Acid-d13; MES Buffer-d13; 2-(4-Morpholino)ethanesulfonic Acid-d13; Perdeuterated MES (partial)
EINECS	Contact for details

Quality Control

Every batch of 2-(n-Morpholino)Ethanesulfonic Acid-D13 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive spectroscopic applications. A Certificate of Analysis (COA) detailing isotopic purity (D-enrichment), chemical purity (by HPLC/NMR), and other critical parameters is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.