Description

Propionyl-D5 Chloride is a deuterium-labeled derivative of propionyl chloride, a key reagent in synthetic organic chemistry. Its primary value lies in its use as a stable isotope-labeled building block, enabling the synthesis of compounds for advanced analytical and research applications. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require precise isotopic labeling for metabolic studies, tracer analysis, and the development of new chemical entities.

Application

• Pharmaceutical Research & Development: As a labeled precursor for synthesizing deuterated active pharmaceutical ingredients (APIs) and metabolites for pharmacokinetic (PK) and drug metabolism studies.
• Analytical Chemistry Standards: Used in the preparation of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to ensure accurate quantitative analysis.
• Agrochemical Development: Incorporation into novel, labeled agrochemical compounds for studying environmental fate, degradation pathways, and residue analysis.
• Organic Synthesis: A versatile reagent for introducing the labeled propionyl group (C2H3C2H2CO-) into complex molecules via acylation reactions.
• Metabolomics & Biomarker Discovery: Enables the tracing of metabolic pathways in biological systems, crucial for understanding disease mechanisms and identifying biomarkers.
• Material Science Research: Potential use in the synthesis of specialty polymers or advanced materials where deuterium labeling is required for structural analysis using techniques like neutron scattering.

Basic Information

Product Name	Propionyl-D5 Chloride
CAS No.	352439-04-4
Molecular Formula	C2H3C2H2COCl or C3D5ClO
Molecular Weight	110.56 g/mol
Synonyms	Perdeuteropropionyl Chloride; Propionyl-d5 Chloride; [2H5]Propionyl Chloride; Deuterated Propionyl Chloride (D5); 3,3,3,2,2-Pentadeuteriopropanoyl Chloride; Pentadeutero-propionyl chloride; Propanoic-d5 acid chloride
EINECS	Contact for details

Quality Control

Our Propionyl-D5 Chloride is manufactured under strict quality control protocols to ensure high isotopic and chemical purity, meeting the stringent requirements of research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D-enrichment), chemical purity by NMR and GC, and impurity profiles. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.