Description

Sodium 3-Hydroxybutyrate-2,2-D2 is a deuterium-labeled sodium salt of the endogenous ketone body, β-hydroxybutyrate. This stable isotope-labeled compound is essential for advanced metabolic research and analytical method development, providing a critical internal standard for precise quantification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and nutritional biochemistry sectors for tracer studies, mass spectrometry, and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the accurate quantification of endogenous 3-hydroxybutyrate in complex biological matrices like plasma, serum, and urine.
• Metabolic Tracer Studies: Used in in vitro and in vivo research to elucidate ketone body metabolism, utilization, and turnover rates.
• NMR Spectroscopy: Serves as a deuterated probe for investigating metabolic pathways and enzyme mechanisms without spectral interference from protons.
• Diagnostic Kit Development: Incorporated into calibration standards and quality control materials for clinical assays measuring ketone levels.
• Pharmaceutical Research: Supports drug metabolism and pharmacokinetics (DMPK) studies for compounds affecting energy metabolism.
• Nutritional Science Research: Applied in studies on ketogenic diets, metabolic health, and energy substrate utilization.

Basic Information

Product Name	Sodium 3-Hydroxybutyrate-2,2-D2
CAS No.	352439-00-0
Molecular Formula	C4H5D2NaO3
Molecular Weight	128.10 g/mol (approx.)
Synonyms	Sodium β-Hydroxybutyrate-2,2-d2; 3-Hydroxybutyric-2,2-d2 Acid Sodium Salt; BHB-d2 Sodium Salt; Sodium (R/S)-3-Hydroxybutyrate-2,2-d2; Sodium DL-3-Hydroxybutyrate-2,2-d2; Ketone Body-d2 Sodium Salt; 2,2-Dideutero-3-hydroxybutanoic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium 3-Hydroxybutyrate-2,2-D2 is produced under strict quality management protocols. Each batch is characterized by advanced analytical techniques including NMR, MS, and HPLC to ensure high chemical purity and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), residual solvents, and identity confirmation is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.