Description

Choline-D13 Chloride CAS NO 352438-97-2 is a stable isotope-labeled analog of the essential nutrient choline, where thirteen hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by pharmaceutical R&D, academic institutions, and contract research organizations (CROs) for mass spectrometry-based studies in neuroscience, lipid metabolism, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a quantitative reference standard in bioanalytical method development and validation for choline and related metabolites.
• Metabolic Pathway Tracing: Enables detailed investigation of choline's role in one-carbon metabolism, phospholipid synthesis, and neurotransmitter (acetylcholine) production.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used in preclinical and clinical research to track the absorption, distribution, metabolism, and excretion of choline-containing drugs or supplements.
• Nutritional and Biomedical Research: Facilitates studies on choline deficiency, fatty liver disease, and cognitive function with high isotopic precision.
• Stable Isotope Labeling in Cell Culture (SILAC) & Proteomics: Can be incorporated into growth media for metabolic labeling in cell-based assays.
• Deuterated Reference Material Manufacturing: Acts as a precursor for synthesizing other deuterium-labeled compounds for research and diagnostic applications.

Basic Information

Item	Details
Product Name	Choline-D13 Chloride
CAS No.	352438-97-2
Molecular Formula	C5D13ClNO
Molecular Weight	139.66 g/mol (for D13 form)
Synonyms	(2-Hydroxyethyl)trimethyl-d9-ammonium-d4 Chloride; (2-Hydroxyethyl-d4)trimethyl-d9-ammonium Chloride; Deuterated Choline Chloride; Choline Chloride-d13; Choline-d13 Chloride; Trimethyl(2-hydroxyethyl)ammonium-d13 Chloride; (β-Hydroxyethyl)trimethylammonium-d13 Chloride
EINECS	Contact for details

Quality Control

Every batch of Choline-D13 Chloride is manufactured and tested under strict quality management systems to ensure exceptional isotopic purity and chemical integrity. Our standard specifications meet the rigorous demands of analytical and research applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing isotopic enrichment (D, atom %), chemical purity (by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability and isotopic purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (D, atom %)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.