Description

(1R,2S)-(-)-Norephedrine-Gamma,Gamma,γ-D3 Hcl is a high-purity, isotopically labeled derivative of norephedrine, a key chiral building block. This compound is essential for advanced analytical and research applications where precise molecular tracking and quantification are required. It is primarily used by pharmaceutical researchers, analytical laboratories, and forensic scientists for use as an internal standard in mass spectrometry, metabolic studies, and pharmacokinetic research.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of norephedrine and related compounds in complex biological matrices like plasma, urine, and tissue samples.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetic (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of sympathomimetic amines.
• Forensic Analysis and Doping Control: Serves as a reference standard in the detection and confirmation of stimulants and related substances in forensic toxicology and sports anti-doping programs.
• Pharmaceutical Reference Standard: Employed in quality control and method development for chiral pharmaceutical ingredients and finished drug products.
• Biochemical Research: A tool for studying adrenergic receptor interactions and the biochemical pathways of catecholamines.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly precise and accurate measurements in clinical chemistry and environmental analysis.

Basic Information

Product Name	(1R,2S)-(-)-Norephedrine-Gamma,Gamma,γ-D3 Hcl
CAS No.	352438-64-3
Molecular Formula	C9H10D3ClNO
Molecular Weight	187.69 g/mol
Synonyms	(-)-Norephedrine-d3 hydrochloride; (1R,2S)-2-Amino-1-phenyl-1-propanol-d3 hydrochloride; L-Norephedrine-d3 HCl; (1R,2S)-Norephedrine-d3 hydrochloride; Phenylpropanolamine-d3 hydrochloride; α-[(1R)-1-Aminoethyl]benzyl alcohol-d3 hydrochloride; Cathine-d3 hydrochloride; Norpseudoephedrine-d3 HCl
EINECS	Contact for details

Quality Control

Our (1R,2S)-(-)-Norephedrine-Gamma,Gamma,γ-D3 Hcl is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chiral purity, and chemical assay. We adhere to relevant guidelines for reference standard materials to ensure reliable and reproducible results in your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.