Description

trans-Cinnamic-D5 Acid CAS NO 352431-48-2 is a high-purity, deuterium-labeled derivative of cinnamic acid, where five hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for applications requiring precise analytical tracking and quantification, offering superior signal resolution and stability compared to non-labeled compounds. It is an essential material for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require reliable internal standards for mass spectrometry and metabolic studies.

Application

• Used as a stable isotope-labeled internal standard for the accurate quantification of cinnamic acid and related metabolites in complex biological matrices via LC-MS/MS and GC-MS.
• Essential in pharmaceutical research for drug metabolism and pharmacokinetics (DMPK) studies, tracing the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Applied in plant biology and natural product research to study phenylpropanoid pathway dynamics and the biosynthesis of flavonoids and lignin.
• Utilized in the development and validation of analytical methods to ensure regulatory compliance and data integrity in quality control laboratories.
• Serves as a key intermediate or tracer in the synthesis of deuterated fine chemicals and agrochemicals for environmental fate studies.

Basic Information

Product Name	trans-Cinnamic-D5 Acid
CAS No.	352431-48-2
Molecular Formula	C9D5H3O2
Molecular Weight	153.18 g/mol
Synonyms	(E)-3-(2,3,4,5,6-Pentadeuteriophenyl)-2-propenoic Acid; (E)-3-(Pentadeuteriophenyl)acrylic Acid; trans-3-(2,3,4,5,6-Pentadeuteriophenyl)acrylic Acid; Cinnamic Acid-d5; (E)-Cinnamic Acid-d5; trans-Cinnamic-d5 Acid; 3-Phenyl-d5-acrylic Acid
EINECS	Contact for details

Quality Control

Our trans-Cinnamic-D5 Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (atom % D), and impurity profiles. We support GMP/GLP-compliant research and development, with specifications tailored to meet the rigorous demands of analytical standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (by HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.