Description

2-Methylbutyric-D9 Acid is a high-purity, deuterium-labeled isotopologue of 2-methylbutyric acid, a branched-chain fatty acid. This compound is essential as a stable isotope-labeled internal standard for precise quantitative analysis in mass spectrometry-based applications. It is primarily used by researchers and quality control laboratories in the pharmaceutical, food & flavor, and metabolomics sectors to ensure accurate measurement of its non-labeled counterpart in complex matrices.

Application

• Internal Standard for Mass Spectrometry (MS): Used in LC-MS and GC-MS for the accurate quantification of 2-methylbutyric acid in biological, food, and pharmaceutical samples.
• Pharmaceutical Research & Development: Critical for pharmacokinetic (PK) and metabolic studies to track drug metabolism and absorption.
• Food & Flavor Analysis: Enables precise measurement of flavor compounds and fermentation byproducts in food science and quality control.
• Metabolomics & Biomarker Discovery: Serves as a stable isotope tracer in metabolic pathway analysis and biomarker validation studies.
• Environmental Testing: Applied in the analysis of organic acids and volatile fatty acids in environmental samples.
• Chemical Synthesis: Acts as a deuterated building block for the synthesis of more complex labeled compounds.

Basic Information

Product Name	2-Methylbutyric-D9 Acid
CAS No.	352431-44-8
Molecular Formula	C5D9HO2
Molecular Weight	113.18 g/mol
Synonyms	2-Methylbutanoic-D9 Acid; (2-Methylbutyryl-D9) Acid; 2-Methylbutyric Acid-d9; DL-2-Methylbutyric-D9 Acid; 2-Methyl-D9-butyric Acid; Deuterated 2-Methylbutyric Acid; Isobutylacetic-D9 Acid; α-Methylbutyric-D9 Acid
EINECS	Contact for details

Quality Control

Our 2-Methylbutyric-D9 Acid is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, which is critical for analytical accuracy. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC/NMR), and other critical parameters. We adhere to cGMP principles for research chemical production, ensuring traceability, consistency, and reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.