Description

L-2-Aminobutyric-3,3-D2 Acid is a stable isotope-labeled analog of the non-proteinogenic amino acid 2-aminobutyric acid, specifically deuterated at the 3,3-positions. This compound is a crucial building block in pharmaceutical research and development, enabling advanced metabolic and pharmacokinetic studies through mass spectrometry and NMR analysis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel drug candidates, proteomics, and stable isotope tracer methodologies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of deuterated active pharmaceutical ingredients (APIs) and novel drug candidates.
• Metabolic Tracer: Used in mass spectrometry-based studies to trace metabolic pathways and understand drug metabolism and disposition (DMPK).
• Internal Standard: Serves as a high-purity internal standard for the accurate quantification of 2-aminobutyric acid and related compounds in bioanalytical assays (LC-MS/MS, GC-MS).
• NMR Spectroscopy: Employed as a probe in nuclear magnetic resonance (NMR) studies to investigate molecular structure, dynamics, and interactions without isotopic interference.
• Proteomics & Biochemical Research: Used in the study of enzyme mechanisms and protein biosynthesis where isotopic labeling is required.
• Isotope-Labeled Reference Material: Provides a certified reference material for analytical method development and validation in regulatory environments.

Basic Information

Product Name	L-2-Aminobutyric-3,3-D2 Acid
CAS No.	352431-37-9
Molecular Formula	C4H7D2NO2
Molecular Weight	105.13 g/mol
Synonyms	(2S)-2-Amino-3,3-dideuteriobutanoic acid; L-2-Amino[3,3-2H2]butyric acid; (S)-2-Amino-3,3-d2-butyric acid; L-α-Amino-β,β-d2-butyric acid; Deuterated L-2-Aminobutyrate; L-2-ABU-3,3-d2; Stable Isotope Labeled 2-Aminobutyric Acid
EINECS	Contact for details

Quality Control

Our L-2-Aminobutyric-3,3-D2 Acid is manufactured under strict quality systems to ensure high isotopic and chemical purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D atom %), chiral purity, chemical purity, and residual solvent content. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation and maintain isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.