Description

Bis(2-Hydroxyethyl)-1,1,2,2-D4-Amine is a deuterated analog of diethanolamine, where four hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This isotopic labeling is critical for applications requiring precise molecular tracking, structural elucidation, and metabolic studies without altering the chemical's fundamental reactivity. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-fidelity isotopic tracers or internal standards for analytical methods like NMR spectroscopy and mass spectrometry.

Application

• Pharmaceutical Research & Development: Serves as a deuterated precursor or intermediate in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for drug metabolism and pharmacokinetics (DMPK) studies.
• Analytical Chemistry & Metabolomics: Used as a stable isotope-labeled internal standard for the accurate quantification of diethanolamine and related compounds in complex biological matrices via LC-MS or GC-MS.
• NMR Spectroscopy Solvent & Reagent: Acts as a deuterium-enriched reagent or solvent component for NMR studies, providing a non-interfering signal for structural analysis of organic molecules and polymers.
• Agrochemical Development: Employed in the synthesis of deuterated agrochemicals to study environmental fate, degradation pathways, and residue analysis.
• Polymer & Material Science: Utilized as a modified monomer or cross-linking agent in the development of specialty polymers where deuterium labeling is used to investigate polymer dynamics, morphology, or for neutron scattering experiments.
• Chemical Mechanism Studies: Provides a powerful tool for elucidating reaction mechanisms and kinetic isotope effects (KIE) in organic and catalytic synthesis.

Basic Information

Product Name	Bis(2-Hydroxyethyl)-1,1,2,2-D4-Amine
CAS No.	352431-07-3
Molecular Formula	C4H7D4NO2
Molecular Weight	109.15 g/mol
Synonyms	Deuterated Diethanolamine; Diethanolamine-d4; 2,2'-Iminobis[ethanol-d4]; Bis(2-hydroxyethyl-d2)amine; DEA-d4; D4-Diethanolamine; N,N-Bis(2-hydroxyethyl-d2)amine; 1,1,2,2-D4-2,2'-Iminodiethanol
EINECS	Contact for details

Quality Control

Our Bis(2-Hydroxyethyl)-1,1,2,2-D4-Amine is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, essential for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR, MS, and HPLC to confirm deuterium incorporation level, chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), assay, and impurity profile is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.