Description

Bis(2-Chloroethyl)-1,1,2,2-D4-Amine Hcl CAS NO 352431-06-2 is a deuterium-labeled analog of a nitrogen mustard compound, where four hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for applications in analytical chemistry and life sciences, where it serves as an internal standard for precise quantification. It is primarily required by researchers and quality control laboratories in the pharmaceutical, agrochemical, and academic sectors for advanced mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies.

Application

• Used as a deuterated internal standard for the accurate quantification of its non-labeled counterpart via LC-MS/MS or GC-MS in pharmacokinetic and metabolism studies.
• Essential in deuterium labeling experiments and mechanistic studies to trace reaction pathways and metabolic fate in pharmaceutical research.
• Applied in analytical method development and validation to ensure regulatory compliance (e.g., FDA, EMA) for drug substance and product testing.
• Utilized in environmental and forensic analysis for the detection and precise measurement of related compounds at trace levels.
• Serves as a key building block or reference material in isotope chemistry research for synthesizing more complex labeled molecules.

Basic Information

Product Name	Bis(2-Chloroethyl)-1,1,2,2-D4-Amine Hcl
CAS No.	352431-06-2
Molecular Formula	C4H5D4Cl2N • HCl
Molecular Weight	200.96 g/mol (for monoisotopic mass)
Synonyms	Nitrogen Mustard-d4 Hydrochloride; 2,2'-Dichlorodiethylamine-d4 Hydrochloride; HN2-d4 HCl; Mechlorethamine-d4 Hydrochloride; Bis(2-chloroethyl)amine-d4 HCl; DL-Norleucine-d4 (Note: This is incorrect but a common mis-association in databases); N,N-Bis(2-chloroethyl)amine-d4 hydrochloride; Mustine-d4 HCl
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality protocols. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment (D-atom %), and impurity profile is provided with each shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.