Description

2-Amino-6-(1,1-Dimethylpropyl)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological and metabolic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a critical raw material for process development and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed as a research tool to study enzyme interactions and receptor binding mechanisms.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for client-specific synthesis projects.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2-Amino-6-(1,1-Dimethylpropyl)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	351981-10-7
Molecular Formula	C15H23NO2S
Molecular Weight	281.41 g/mol
Synonyms	Methyl 2-amino-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-Amino-6-tert-pentyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; 6-(1,1-Dimethylpropyl)-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; Tetrahydrobenzothiophene methyl ester derivative; CAS 351981-10-7
EINECS	Contact for details

Quality Control

Our 2-Amino-6-(1,1-Dimethylpropyl)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and REACH requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.