Description

4-Bromo-5-Fluoroisoquinoline is a high-purity, halogenated isoquinoline derivative, a crucial building block in advanced organic synthesis. Its value lies in its dual functionalization, which enables precise molecular modifications for creating complex pharmacophores. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the biological activity of the fluorinated isoquinoline scaffold.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Catalyst Ligand Synthesis: The bromo and fluoro substituents make it a versatile starting point for synthesizing novel ligands used in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	4-Bromo-5-Fluoroisoquinoline
CAS No.	351457-58-4
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	5-Fluoro-4-bromoisoquinoline; 4-Bromo-5-fluoro-isoquinoline; Isoquinoline, 4-bromo-5-fluoro-; 351457-58-4; 4-Br-5-F-isoquinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.