Description

4-Ethynylbenzyl Bromide is a versatile and highly reactive aromatic building block featuring both a benzylic bromide and a terminal alkyne functional group. This dual functionality makes it a critical intermediate for constructing complex molecular architectures via cross-coupling and click chemistry reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery, ligand synthesis, and polymer modification.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anticancer drug candidates.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and plant growth regulators requiring specific aromatic-alkyne motifs.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for synthesizing specialty polymers, dendrimers, and conductive materials.
• Bioconjugation & Probe Development: Ideal for labeling biomolecules (proteins, peptides, nucleic acids) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Ligand & Catalyst Preparation: Employed in the synthesis of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A fundamental reagent for exploring new synthetic methodologies and constructing molecular libraries for screening.

Basic Information

Product Name	4-Ethynylbenzyl Bromide
CAS No.	351002-91-0
Molecular Formula	C9H7Br
Molecular Weight	195.06 g/mol
Synonyms	1-(Bromomethyl)-4-ethynylbenzene; p-Ethynylbenzyl Bromide; 4-(Bromomethyl)phenylacetylene; (4-Bromomethylphenyl)acetylene; 4-Ethynylbenzylbromide; 4-Ethynyl-α-bromotoluene; α-Bromo-4-ethylnyltoluene
EINECS	Contact for details

Quality Control

Our 4-Ethynylbenzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data including HPLC, GC, and NMR to verify identity and purity. Certificates of Analysis (COA) are available for every batch upon request, supporting compliance with research and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.