Description

2-Amino-4-(4-Chloro-Phenyl)-Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, offering a versatile scaffold for molecular diversification. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of thiophene-based drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Used in the research and development of organic semiconductors, conductive polymers, and advanced organic electronic materials.
• Chemical Synthesis: Acts as a versatile synthon for constructing complex heterocyclic systems through reactions like Suzuki coupling, Buchwald-Hartwig amination, and cyclization.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for medicinal chemistry programs and method development.
• Dye & Pigment Intermediate: Potential use in the synthesis of specialized dyes and pigments due to its conjugated thiophene core.

Basic Information

Item	Information
Product Name	2-Amino-4-(4-Chloro-Phenyl)-Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	350997-10-3
Molecular Formula	C12H10ClNO2S
Molecular Weight	267.73 g/mol
Synonyms	Methyl 2-Amino-4-(4-chlorophenyl)thiophene-3-carboxylate; 2-Amino-4-(4-chlorophenyl)-3-thiophenecarboxylic Acid Methyl Ester; 4-(4-Chlorophenyl)-2-aminothiophene-3-carboxylic Acid Methyl Ester; 350997-10-3; Methyl 2-amino-4-(p-chlorophenyl)thiophene-3-carboxylate; 2-Amino-4-(p-chlorophenyl)thiophene-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(4-Chloro-Phenyl)-Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports your R&D and scale-up processes with reliable, traceable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.