Description

2-Butanone-D8 is a deuterated isotopologue of the common industrial solvent 2-butanone (methyl ethyl ketone), where all eight hydrogen atoms are replaced by deuterium. This high isotopic purity makes it an invaluable internal standard and tracer in quantitative analytical chemistry, particularly for mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. It is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, interference-free analysis of ketone compounds and reaction pathways.

Application

• Internal Standard for GC/MS and LC/MS: Used for the accurate quantification of 2-butanone and related compounds in complex matrices like environmental samples, biological fluids, and polymer extracts.
• NMR Spectroscopy Solvent & Tracer: Serves as a deuterated solvent for NMR studies and as a tracer to elucidate reaction mechanisms and kinetic isotope effects in organic synthesis.
• Pharmaceutical Metabolism and PK/PD Studies: Employed as a stable isotope-labeled analog to track the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical agents.
• Polymer Science Research: Acts as a labeled solvent or reactant in studies of polymerization kinetics, plasticizer migration, and polymer degradation.
• Environmental Analysis: A critical reference standard for monitoring volatile organic compound (VOC) emissions and analyzing water or soil contamination.
• Deuterium Labeling in Organic Synthesis: Used as a building block for introducing deuterium labels into more complex molecules for spectroscopic or mechanistic studies.

Basic Information

Product Name	2-Butanone-D8
CAS No.	350820-09-6
Molecular Formula	C4D8O
Molecular Weight	80.17 g/mol
Synonyms	Deuterated Methyl Ethyl Ketone; MEK-d8; Butanone-1,1,1,3,3,3-d6,2,4,4,4-d4; Methyl Ethyl Ketone-d8; 3,3,4,4,4-Pentadeutero-1,1,1,3-tetradeuterobutan-2-one; Ethyl Methyl Ketone-d8; 2-Oxobutane-d8
EINECS	Contact for details

Quality Control

Every batch of 2-Butanone-D8 is produced and analyzed under strict quality management systems to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR and mass spectrometric analysis, to ensure compliance with industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) detailing isotopic enrichment (typically >99 atom % D), chemical purity, and physical properties are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong oxidizing agents. Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Recommended storage temperature: 2-25°C.

Specification

Item	Specification
Appearance	Clear, Colorless Liquid
Identification (IR)	Conforms
Isotopic Purity (Atom % D)	≥ 99.0% (by NMR/MS)
Chemical Purity (GC)	≥ 99.5%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.