Description

(1R,2S)-(-)-Ephedrine-D6 Hcl (Dimethyl-D6) is a high-purity, deuterium-labeled internal standard essential for precise analytical quantification. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based methods, eliminating matrix effects and instrumental drift. It is primarily required by pharmaceutical R&D laboratories, forensic analysis units, and clinical research organizations for drug metabolism studies, pharmacokinetic profiling, and regulatory bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in the bioanalysis of ephedrine and related compounds in biological matrices (plasma, serum, urine).
• Pharmaceutical Metabolism & PK/PD Studies: Enables accurate tracking and quantification of the parent drug and its metabolites in absorption, distribution, metabolism, and excretion (ADME) research.
• Forensic and Doping Control Analysis: Provides definitive quantification in the detection of ephedrine and pseudoephedrine in forensic toxicology and anti-doping programs.
• Method Development and Validation: Serves as a critical component for developing, validating, and transferring GLP/GCP-compliant analytical methods.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques where the highest level of precision is required.
• Quality Control in Reference Material Production: Used in the certification and quality control of ephedrine reference standards and certified reference materials (CRMs).

Basic Information

Product Name	(1R,2S)-(-)-Ephedrine-D6 Hcl (Dimethyl-D6)
CAS No.	350820-08-5
Molecular Formula	C10H9D6ClNO
Molecular Weight	207.73 g/mol
Synonyms	(-)-Ephedrine-d6 hydrochloride; (1R,2S)-(-)-1-Phenyl-2-methylamino-1-propanol-d6 hydrochloride; 1R,2S-Ephedrine-d6 HCl; Ephedrine-(N-methyl-d3, phenyl-d5) hydrochloride; Deuterated Ephedrine HCl; [2H6]-Ephedrine hydrochloride; N-Methyl-d3, Phenyl-d5 Ephedrine Hydrochloride; Internal Standard Ephedrine-d6
EINECS	Contact for details

Quality Control

Every batch of (1R,2S)-(-)-Ephedrine-D6 Hcl (Dimethyl-D6) is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments, including chemical purity, isotopic purity (enrichment), and chromatographic purity verified by NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting batch-specific results. Our quality commitment ensures consistency for critical applications in pharmaceutical development and forensic science.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.