Description

4-Aminobenzoic-2, 3, 5, 6-D4 Acid is a deuterium-labeled isotopologue of para-aminobenzoic acid (PABA), a key biochemical building block. This high-purity, stable-labeled compound is essential for applications requiring precise internal standards and metabolic pathway tracing. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced analytical chemistry, drug metabolism studies (DMPK), and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for Mass Spectrometry: Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of PABA and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds and nutrients.
• Deuterated API Synthesis: Acts as a labeled precursor in the research and development of deuterium-enriched drugs, where deuterium substitution can alter pharmacokinetic properties.
• Biochemical Research: Employed in mechanistic studies of folate biosynthesis and other enzymatic pathways where PABA is a substrate or cofactor.
• Analytical Method Development: Provides a stable isotope-labeled compound for validating and calibrating sensitive analytical methods in regulatory environments.
• Nutritional Science Studies: Used in research investigating bacterial vitamin synthesis and the role of PABA in microbial ecosystems.

Basic Information

Product Name	4-Aminobenzoic-2, 3, 5, 6-D4 Acid
CAS No.	350820-01-8
Molecular Formula	C7D4H3NO2
Molecular Weight	141.16 g/mol
Synonyms	4-Amino-D4-benzoic Acid; Para-Aminobenzoic Acid-d4; PABA-d4; Vitamin B10-d4; 4-Carboxy-D4-aniline; 4-Amino-D4-benzene-1-carboxylic Acid; Deutero-PABA; [2,3,5,6-2H4]-4-Aminobenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-Aminobenzoic-2, 3, 5, 6-D4 Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm chemical and isotopic identity, purity, and absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment (D-atom %), and chromatographic purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.