Description

Rimantadine-D4 HCl (Ethyl-D4) is a deuterated derivative of the antiviral drug rimantadine, specifically labeled with four deuterium atoms on the ethyl side chain. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reliability in analytical methods. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of rimantadine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research (DMPK): Used to investigate metabolic pathways and identify metabolites without interference from the analyte.
• Bioanalytical Method Development and Validation: Serves as a key component in establishing robust, sensitive, and regulatory-compliant analytical assays.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification of the active pharmaceutical ingredient (API).
• Forensic and Anti-Doping Analysis: Provides a reliable reference for the detection and confirmation of rimantadine in forensic toxicology and sports doping control.

Basic Information

Item	Details
Product Name	Rimantadine-D4 HCl (Ethyl-D4)
CAS No.	350818-67-6
Molecular Formula	C12H17D4ClN
Molecular Weight	215.78 g/mol
Synonyms	Rimantadine-d4 hydrochloride; α-Methyl-1-adamantanemethylamine-d4 hydrochloride; 1-(1-Adamantyl)ethanamine-d4 hydrochloride; (RS)-Rimantadine-d4 HCl; Deuterated Rimantadine HCl; Flumadine-d4 (labeled analog); Ethyl-d4 rimantadine hydrochloride; Adamantane-d4 derivative
EINECS	Contact for details

Quality Control

Every batch of Rimantadine-D4 HCl (Ethyl-D4) is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing batch-specific results for identity, purity, isotopic enrichment, and residual solvents is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.