Description

trans-4-Hydroxy-2-Nonenal-5,5,6,6,7,7,8,8,9,9,9-D11 Dimethyl Acetal is a high-purity, deuterium-labeled derivative of 4-hydroxy-2-nonenal (4-HNE), a key biomarker of lipid peroxidation. This compound is specifically designed for use as an internal standard in mass spectrometry, enabling precise quantification in complex biological matrices. It is essential for researchers and analytical laboratories in pharmaceutical development, clinical diagnostics, and nutritional science who require accurate measurement of oxidative stress markers.

Application

• Mass Spectrometry Internal Standard: Primary use as a stable isotope-labeled internal standard for the accurate quantification of 4-HNE and related aldehydes via LC-MS/MS and GC-MS.
• Biomarker Research: Critical for studies investigating oxidative stress, lipid peroxidation, and their roles in diseases such as atherosclerosis, neurodegenerative disorders, and cancer.
• Pharmaceutical R&D: Used in drug discovery and development to assess the efficacy of antioxidant compounds and therapies targeting oxidative damage.
• Clinical & Diagnostic Assays: Enables the development and validation of high-sensitivity assays for measuring oxidative stress biomarkers in patient samples.
• Food & Nutritional Science: Applied in research on lipid oxidation in foods, supplements, and the impact of diet on in vivo oxidative stress levels.
• Toxicology Studies: Facilitates the investigation of chemical-induced oxidative damage and cellular toxicity mechanisms.

Basic Information

Item	Details
Product Name	trans-4-Hydroxy-2-Nonenal-5,5,6,6,7,7,8,8,9,9,9-D11 Dimethyl Acetal
CAS No.	350818-64-3
Molecular Formula	C₁₁H₁₃D₁₁O₃
Molecular Weight	~223.34 g/mol (for deuterated form)
Synonyms	4-HNE-d11 Dimethyl Acetal; 4-Hydroxy-2-nonenal-d11 Dimethyl Acetal; (2E)-4-Hydroxynon-2-enal-5,5,6,6,7,7,8,8,9,9,9-d11 Dimethyl Acetal; HNE-d11 DMA; Lipid Peroxidation Marker-d11; Deuterated 4-HNE Dimethyl Acetal; trans-4-HNE-d11 Dimethyl Acetal; Oxidative Stress Biomarker Internal Standard-d11
EINECS	Contact for details

Quality Control

Every batch of our trans-4-Hydroxy-2-Nonenal-D11 Dimethyl Acetal is produced and analyzed under strict quality protocols. We guarantee high chemical and isotopic purity to ensure optimal performance as a mass spectrometry standard. Our quality assurance includes comprehensive testing via NMR, HPLC, and MS to confirm structure, purity, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term stability, keep the container sealed and allow it to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 90%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (e.g., methanol, acetonitrile, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.