Description

4-Methoxytoluene-2,3,5,6-D4 is a deuterium-labeled isotopologue of 4-methoxytoluene (p-methylanisole), where four hydrogen atoms at the 2, 3, 5, and 6 positions of the aromatic ring are replaced with deuterium. This compound is an essential stable isotope-labeled internal standard for analytical chemistry, enabling precise quantification and method validation in complex matrices. It is primarily used by researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental analysis sectors.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference in GC-MS and LC-MS analyses for accurate measurement of 4-methoxytoluene and related compounds.
• Pharmaceutical Research: Critical for pharmacokinetic studies, drug metabolism research (DMPK), and bioanalytical method development to ensure data integrity.
• Environmental Analysis: Employed in the trace analysis of environmental pollutants, metabolites, and degradation products in water, soil, and air samples.
• Agrochemical Testing: Facilitates the reliable quantification of pesticides, herbicides, or their metabolites in crop and food safety testing.
• Chemical Synthesis Research: Serves as a labeled starting material or tracer in mechanistic studies and synthetic chemistry to track reaction pathways.
• Forensic and Toxicology Labs: Supports accurate analysis in forensic toxicology for the detection and quantification of specific substances.
• Quality Control & Assurance: Ensures the accuracy and precision of analytical methods in industrial QC laboratories.
• NMR Solvent & Reagent: Can be utilized as a deuterated solvent or reagent in Nuclear Magnetic Resonance (NMR) spectroscopy.

Basic Information

Product Name	4-Methoxytoluene-2,3,5,6-D4
CAS No.	350818-57-4
Molecular Formula	C8H4D4O
Molecular Weight	124.20 g/mol
Synonyms	p-Methylanisole-d4; 1-Methoxy-4-methylbenzene-2,3,5,6-d4; 4-Methylanisole-d4; Deuterated p-Methylanisole; 4-Methoxy-1-methylbenzene-2,3,5,6-d4; Methyl-p-tolyl ether-d4; p-Methoxytoluene-d4; [2,3,5,6-2H4]-4-Methoxytoluene
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high isotopic purity and chemical integrity, which are critical for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, GC-MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % D), chemical purity, and analytical data is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR / NMR)	Conforms to structure
Chemical Purity (GC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS or NMR)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.