Description

(R)-4-Methyl-1,2,3,4-Tetrahydroisoquinoline is a chiral, non-racemic organic compound belonging to the tetrahydroisoquinoline class, a privileged scaffold in medicinal chemistry. This high-purity intermediate is critical for the synthesis of enantiomerically pure pharmaceuticals and fine chemicals, where stereochemical integrity directly impacts biological activity and product efficacy. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential central nervous system (CNS) agents, alkaloid derivatives, and other bioactive molecules.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in stereoselective synthesis.
• Agrochemical Research: Used in the development of enantiopure pesticides and herbicides where specific stereochemistry is required for optimal activity.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in R&D and manufacturing.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry for studying structure-activity relationships and developing novel synthetic methodologies.

Basic Information

Product Name	(R)-4-Methyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	350508-38-2
Molecular Formula	C10H13N
Molecular Weight	147.22 g/mol
Synonyms	(R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline; (R)-4-Methyl-THIQ; (R)-4-Methyl-1,2,3,4-tetrahydro-isoquinoline; (4R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline; (R)-4-Methyl-3,4-dihydro-1H-isoquinoline; (R)-4-Methyl-1,2,3,4-tetrahydroisoquinolin; (R)-4-Methyl-THIQ base
EINECS	Contact for details

Quality Control

Our (R)-4-Methyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.