Description

3,5-Bis(tert-Butyldimethylsilyloxy)Phenylboronic Acid is a high-purity, organosilicon-protected boronic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the dual silyl protection of the phenolic hydroxyl groups, which provides enhanced stability and selectivity in demanding coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing complex molecules, such as active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis.
• Materials Science Research: Employed in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological processes and target engagement.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	3,5-Bis(tert-Butyldimethylsilyloxy)Phenylboronic Acid
CAS No.	350035-52-8
Molecular Formula	C18H35BO4Si2
Molecular Weight	382.46 g/mol
Synonyms	[3,5-Bis[(1,1-dimethylethyl)dimethylsilyl]oxy]benzeneboronic Acid; 3,5-Bis-O-(tert-butyldimethylsilyl)phenylboronic Acid; 3,5-Di-O-TBDMS Phenylboronic Acid; 3,5-Bis(TBDMSO)Phenylboronic Acid; 3,5-Bis(tert-butyldimethylsiloxy)benzeneboronic Acid; Boronic acid, B-[3,5-bis[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-; 3,5-Bis[(tert-butyldimethylsilyl)oxy]phenylboronic Acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(tert-Butyldimethylsilyloxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material's suitability for sensitive applications in GMP-compliant pharmaceutical synthesis and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.