Description

Enalaprilat-D5 is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy in quantitative bioanalysis. This stable isotope-labeled compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and related techniques, where it compensates for matrix effects and instrument variability. It is an essential tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) conducting pharmacokinetic studies, therapeutic drug monitoring, and metabolism research for the antihypertensive drug enalaprilat.

Application

• Quantitative LC-MS/MS Analysis: Serves as a critical internal standard for the precise and accurate quantification of enalaprilat in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Enables reliable measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Therapeutic Drug Monitoring (TDM): Supports clinical assays that monitor enalaprilat levels in patients to optimize dosage and ensure therapeutic efficacy while minimizing side effects.
• Metabolite Identification and Profiling: Aids in mass spectrometry-based studies to identify and quantify metabolites of enalapril and related compounds.
• Method Development and Validation: Used as a reference standard to develop, optimize, and validate robust analytical methods in compliance with Good Laboratory Practice (GLP) and regulatory guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assays for drug substance and finished product testing.

Basic Information

Product Name	Enalaprilat-D5
CAS No.	349554-01-4
Molecular Formula	C18H19D5N2O5
Molecular Weight	~ 351.41 g/mol
Synonyms	(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline-d5; Enalaprilat (phenyl-d5); Enalaprilat-d5; Deuterated Enalaprilat; Enalaprilat Internal Standard; 2-[[1-(Ethoxycarbonyl)-3-phenyl-d5-propyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of Enalaprilat-D5 is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, isotopic enrichment, and impurity profiles, ensuring traceability and compliance with your method validation requirements. Our quality commitment supports applications demanding high reliability, including regulatory submissions to agencies like the FDA and EMA.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.