Description

Dl-Mevalonolactone-4,4,5,5-D4 is a deuterium-labeled analog of mevalonolactone, a key intermediate in the isoprenoid biosynthesis pathway. This stable isotope-labeled compound is essential for metabolic flux analysis and mechanistic studies in biochemical research, providing critical insights without interfering with natural biological processes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for advanced deuterium labeling, tracer studies, and the development of novel diagnostic agents.

Application

• Isotopic Tracer in Metabolic Research: Used to trace and quantify the mevalonate pathway flux in studies of cholesterol biosynthesis, steroid hormone production, and terpenoid metabolism.
• Deuterium-Labeled Standard for Analytical Chemistry: Serves as an internal standard in LC-MS, GC-MS, and NMR analyses for the accurate quantification of mevalonate pathway metabolites in complex biological matrices.
• Precursor for Labeled Compound Synthesis: A critical building block for the synthesis of more complex deuterium-labeled isoprenoids, sterols, and pharmaceuticals.
• Drug Discovery & Development: Facilitates pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies of drug candidates targeting the HMG-CoA reductase pathway.
• Biochemical Mechanism Elucidation: Enables detailed investigation of enzyme kinetics and reaction mechanisms within the isoprenoid biosynthesis pathway using deuterium isotope effects.

Basic Information

Product Name	Dl-Mevalonolactone-4,4,5,5-D4
CAS No.	349553-98-6
Molecular Formula	C6H6D4O3
Molecular Weight	136.17 g/mol
Synonyms	3-Hydroxy-3-methyl-5-oxotetrahydrofuran-2,2,3,3-d4; (±)-Mevalonolactone-4,4,5,5-d4; DL-Mevalonic acid lactone-d4; 3-Hydroxy-3-methyl-δ-valerolactone-d4; 5-Hydroxy-3-methylpentanoic acid 5-lactone-d4; Mevalolactone-d4; Racemic Mevalonolactone-d4
EINECS	Contact for details

Quality Control

Our Dl-Mevalonolactone-4,4,5,5-D4 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry, to confirm isotopic enrichment (D-incorporation) and chemical purity. Certificates of Analysis (COA) detailing assay, isotopic purity, and impurity profiles are provided to ensure reliable and reproducible results for your research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.