Description

3-Borono-5-Methoxy-1H-Indole-1-Carboxylic Acid 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, serving as a critical building block in modern synthetic chemistry. This compound is valued for its unique molecular architecture, which combines a protected carboxylic acid group with a reactive boronic acid pinacol ester moiety, enabling precise cross-coupling reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic targets and active pharmaceutical ingredients (APIs).

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key electrophilic partner for constructing carbon-carbon bonds in medicinal chemistry programs.
• Pharmaceutical Intermediate: For the research and development of novel indole-based drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: In the creation of advanced crop protection agents with complex heterocyclic cores.
• Material Science Research: As a precursor for organic electronic materials and functional polymers.
• Chemical Biology Probes: For labeling and studying biological systems due to its reactive handle for bioconjugation.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial manufacturing of fine chemicals.

Basic Information

Product Name	3-Borono-5-Methoxy-1H-Indole-1-Carboxylic Acid 1-(1,1-Dimethylethyl) Ester
CAS No.	348640-19-7
Molecular Formula	C16H20BNO5
Molecular Weight	317.15 g/mol
Synonyms	5-Methoxy-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester 3-boronic acid; 3-Borono-5-methoxy-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 3-borono-5-methoxy-1H-indole-1-carboxylate; 5-Methoxy-1-(tert-butoxycarbonyl)indole-3-boronic acid; BOC-5-Methoxyindole-3-boronic acid; 3-Bpin-5-MeO-1H-indole-1-Boc (common abbreviation); 1-Boc-5-methoxyindole-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 3-Borono-5-Methoxy-1H-Indole-1-Carboxylic Acid 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light may affect purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.