Description

Nicotinamide-2,4,5,6-D4 is a stable isotope-labeled analog of nicotinamide, a vital form of vitamin B3. This high-purity deuterated compound is essential for advanced analytical and metabolic research, providing an internal standard for precise quantification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutritional science, and life sciences sectors for applications requiring high specificity and accuracy.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of nicotinamide and its metabolites in complex biological matrices like plasma, serum, and tissue samples.
• Metabolic Pathway Tracing: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the absorption, distribution, metabolism, and excretion of vitamin B3.
• Nutritional Research: Enables precise measurement of nicotinamide levels in fortified foods, dietary supplements, and clinical nutrition studies.
• Drug Development & Biomarker Discovery: Supports bioanalytical method development and validation for drug candidates targeting NAD+ pathways.
• Stable Isotope Dilution Assays: Provides the reference material for high-accuracy assays in clinical diagnostics and research laboratories.

Basic Information

Product Name	Nicotinamide-2,4,5,6-D4
CAS No.	347841-88-7
Molecular Formula	C6H2D4N2O
Molecular Weight	126.14 g/mol
Synonyms	Deuterated Nicotinamide; Nicotinamide-d4; Pyridine-3-carboxamide-2,4,5,6-d4; Vitamin B3-d4; Niacinamide-d4; 3-Pyridinecarboxamide-2,4,5,6-d4; Nicotinic acid amide-d4; NSC 13128-d4
EINECS	Contact for details

Quality Control

Our Nicotinamide-2,4,5,6-D4 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled to minimize prolonged exposure to light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Isotopic Enrichment (MS)	≥ 99.0% (M+4)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.