Description

Ursodeoxycholic-2,2,4,4-D4 Acid CAS NO 347841-46-7 is a deuterium-labeled analog of the primary bile acid ursodeoxycholic acid (UDCA), a critical compound for advanced pharmaceutical research and development. This high-purity, isotopically labeled standard is essential for creating highly sensitive and specific analytical methods, enabling precise quantification and metabolic pathway tracing. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control for deuterated drug substances.

Application

• Internal Standard for Quantitative Bioanalysis: Used in LC-MS/MS and GC-MS methods for the accurate quantification of ursodeoxycholic acid and its metabolites in biological matrices like plasma, serum, and bile.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Serves as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of UDCA and related compounds.
• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Acts as a key intermediate or reference standard in the development and quality control of deuterium-enriched pharmaceutical products.
• Metabolic Pathway Research: Enables detailed studies of bile acid metabolism, cholestatic liver diseases, and related biochemical pathways in preclinical models.
• Quality Control and Method Validation: Provides a critical reference material for validating analytical procedures in GMP and GLP environments to ensure accuracy and reproducibility.

Basic Information

Product Name	Ursodeoxycholic-2,2,4,4-D4 Acid
CAS No.	347841-46-7
Molecular Formula	C₂₄H₃₆D₄O₄
Molecular Weight	396.59 g/mol
Synonyms	UDCA-d4; Ursodiol-d4; 3α,7β-Dihydroxy-5β-cholan-24-oic-2,2,4,4-d4 Acid; Deoxycholic-2,2,4,4-d4 Acid (7β-hydroxy); (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d4 Acid; Ursodeoxycholic Acid-d4; Deuterated Ursodeoxycholic Acid
EINECS	Contact for details

Quality Control

Our Ursodeoxycholic-2,2,4,4-D4 Acid is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment, and identification. We support research and development under quality frameworks including GLP and cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.