Description

Acetylcholine-D16 Bromide is a stable isotope-labeled analog of the essential neurotransmitter acetylcholine, where sixteen hydrogen atoms are replaced by deuterium. This high-purity compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical workflows. It is indispensable for researchers and quality control laboratories in the pharmaceutical, biotechnology, and neurochemical research sectors who require precise quantification of acetylcholine in complex biological matrices.

Application

• Primary use as a deuterated internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of acetylcholine.
• Enabling accurate pharmacokinetic and pharmacodynamic studies in drug discovery and development for neurological and cognitive disorders.
• Quantification of acetylcholine levels in neuroscience research, including studies on synaptic transmission, memory, and learning.
• Biomarker analysis in clinical research for conditions such as Alzheimer's disease, myasthenia gravis, and other cholinergic system dysfunctions.
• Quality control and method validation in pharmaceutical manufacturing where precise assay of cholinergic compounds is required.
• Metabolomics and bioanalytical research to study cholinergic metabolism and pathway dynamics.

Basic Information

Product Name	Acetylcholine-D16 Bromide
CAS No.	347841-43-4
Molecular Formula	C7D16BrNO2
Molecular Weight	Approx. 208.16 g/mol (Contact for exact details)
Synonyms	(2-Acetoxyethyl)trimethyl-d9-ammonium-d7 Bromide; Deuterated Acetylcholine Bromide; ACh-D16 Br; Acetylcholine (N,N,N-trimethyl-d9, 1,1,2,2-d4, 2-hydroxyethyl-1,1,2,2-d4) Bromide; Acetylcholine-d16 Bromide Salt; [N,N,N-Trimethyl-d9, 1,1,2,2-D4, 2-Hydroxyethyl-1,1,2,2-D4]acetylcholine Bromide; 2-(Acetyloxy)-N,N,N-trimethyl-d9-ethanaminium-d7 Bromide
EINECS	Contact for details

Quality Control

Every batch of Acetylcholine-D16 Bromide is manufactured and analyzed under strict quality protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) providing detailed results for isotopic purity, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term stability, consider storage in a desiccator or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.