Description

L-Ornithine Hcl (3,3,4,4,5,5-D6) is a high-purity, deuterium-labeled derivative of the amino acid L-Ornithine, a key intermediate in the urea cycle. This stable isotope-labeled compound is essential for advanced research and development where precise metabolic tracing and quantification are required. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and diagnostic developers working on metabolic studies, biomarker discovery, and the development of internal standards for mass spectrometry.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate measurement of endogenous L-Ornithine levels in biological samples.
• Metabolic Pathway Tracing: Used in stable isotope-resolved metabolomics (SIRM) to elucidate the urea cycle, arginine biosynthesis, and polyamine metabolism in cell cultures, tissues, or whole organisms.
• Pharmaceutical R&D: Facilitates drug metabolism and pharmacokinetic (DMPK) studies for compounds targeting urea cycle disorders, liver function, or related metabolic pathways.
• Clinical Diagnostics: Enables the development of high-precision clinical assays for diagnosing conditions like hyperammonemia, ornithine transcarbamylase (OTC) deficiency, and other inborn errors of metabolism.
• Biochemical Research: Acts as a labeled precursor in enzymatic studies and in vitro assays to investigate enzyme kinetics and mechanisms within the urea cycle.
• Nutritional Science Studies: Employed in research exploring amino acid supplementation, nitrogen metabolism, and related nutritional interventions.

Basic Information

Product Name	L-Ornithine Hcl (3,3,4,4,5,5-D6)
CAS No.	347841-40-1
Molecular Formula	C5H7D6ClN2O2
Molecular Weight	169.66 g/mol (for D6 isotopologue)
Synonyms	(2S)-2,5-Diaminopentanoic-3,3,4,4,5,5-d6 acid hydrochloride; L-Ornithine-d6 hydrochloride; Ornithine-3,3,4,4,5,5-d6 monohydrochloride; (S)-2,5-Diaminovaleric-3,3,4,4,5,5-d6 acid hydrochloride; L-(+)-Ornithine-d6 HCl; L-Ornithine monohydrochloride-d6; (S)-Ornithine-d6 hydrochloride
EINECS	Contact for details

Quality Control

Our L-Ornithine Hcl (3,3,4,4,5,5-D6) is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, meeting the stringent requirements of analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to rigorous quality management protocols to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and stored in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chiral Purity (Optical Rotation)	[α]20/D: +15.0° to +20.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.