Description

Trimethyl-D6-Amine Hcl (Dimethyl-D6) is a deuterated derivative of trimethylamine hydrochloride, a key building block and internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and NMR spectroscopy. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced material sectors for method development, metabolic studies, and precise quantification.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a stable, non-interfering reference compound for the accurate quantification of trimethylamine and related metabolites in complex biological and environmental samples.
• NMR Spectroscopy Solvent & Reagent: Serves as a deuterated reagent or shift reference in nuclear magnetic resonance studies, providing a clean spectral background without proton interference.
• Pharmaceutical Research & Development: Critical in drug metabolism and pharmacokinetics (DMPK) studies for tracing metabolic pathways and ensuring analytical method validation.
• Agrochemical Analysis: Employed in the development and validation of analytical methods for pesticide residue analysis and environmental fate studies.
• Chemical Synthesis Intermediate: Acts as a specialized, labeled precursor for synthesizing deuterated compounds in medicinal chemistry and material science.
• Clinical Diagnostics: Used in the development of advanced diagnostic assays, particularly for conditions linked to trimethylamine N-oxide (TMAO) and related biomarkers.

Basic Information

Product Name	Trimethyl-D6-Amine Hcl (Dimethyl-D6)
CAS No.	347840-14-6
Molecular Formula	C3D6ClN • (HCl) or C3H3D6ClN
Molecular Weight	117.61 g/mol (for C3D6ClN • HCl)
Synonyms	Perdeuterotrimethylamine Hydrochloride; Trimethylamine-d9 Hydrochloride; (CD3)3N • HCl; N,N,N-Trimethyl-d9-amine Hydrochloride; Deuterated TMA HCl; TMA-d9 HCl; Trimethylamine-d9 HCl; (Methyl-d3)3N•HCl
EINECS	Contact for details

Quality Control

Every batch of Trimethyl-D6-Amine Hcl is produced and tested under strict quality management systems to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity, and specific impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting regulatory filings in pharmaceutical and agrochemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS or NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.