Description

2-Chloroaniline-4,6-D2 CAS NO 347840-10-2 is a deuterium-labeled derivative of 2-chloroaniline, serving as a critical stable isotope-labeled internal standard and tracer compound. Its primary value lies in enabling precise quantitative analysis and metabolic pathway studies in complex matrices, where it compensates for analyte loss and ionization variability. This high-purity labeled compound is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental testing sectors who require the highest level of accuracy in mass spectrometry and NMR-based methods.

Application

• Internal Standard for LC-MS/MS & GC-MS: Used for the accurate quantification of 2-chloroaniline and related metabolites in pharmacokinetic and bioanalytical studies.
• Metabolic Pathway Tracing: Employed in drug metabolism and disposition (DMPK) research to elucidate biotransformation pathways in vivo and in vitro.
• Environmental Analysis: Acts as a surrogate or standard in the detection and measurement of chloroaniline residues in soil, water, and agricultural products.
• Pharmaceutical Impurity Profiling: Facilitates the identification and quantification of genotoxic impurities (GTIs) and degradation products in active pharmaceutical ingredients (APIs).
• Synthetic Intermediate: Used in the synthesis of more complex deuterium-labeled compounds for research and development.
• Quality Control & Method Validation: Critical for developing and validating robust analytical methods in compliance with ICH and FDA guidelines.

Basic Information

Item	Detail
Product Name	2-Chloroaniline-4,6-D2
CAS No.	347840-10-2
Molecular Formula	C6H3D2ClN
Molecular Weight	130.58 g/mol (approx.)
Synonyms	2-Chloroaniline-d2; 2-Chloro-4,6-dideuteroaniline; 4,6-Dideutero-2-chloroaniline; 2-Chloroaniline (4,6-D2); 2-Chloro-1-amine-4,6-d2-benzene; Deutero-labeled 2-chloroaniline; 2-CA-d2; o-Chloroaniline-4,6-d2
EINECS	Contact for details

Quality Control

Every batch of 2-Chloroaniline-4,6-D2 is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and Mass Spectrometry to confirm identity, assay, and deuterium incorporation. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to ensure traceability and support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.