Description

2-Methyl-D3-Succinic-2,3,3-D3 Acid is a high-purity, isotopically labeled derivative of 2-methylsuccinic acid, where specific hydrogen atoms are replaced with deuterium (D). This compound is a critical tool in advanced analytical chemistry, providing a stable, non-radioactive isotopic tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug development, biomarker discovery, and detailed mechanistic investigations using techniques like mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Serves as a critical reference compound for the accurate quantification of endogenous 2-methylsuccinic acid and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate biochemical pathways, including those related to fatty acid metabolism and the Krebs cycle, by tracking the incorporation of the deuterium label.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Enables precise tracking of drug metabolites and understanding of drug absorption, distribution, metabolism, and excretion (ADME) profiles in development pipelines.
• Biomarker Discovery and Validation: Facilitates the identification and accurate measurement of potential disease biomarkers in fields like oncology, neurology, and metabolic disorders.
• NMR Spectroscopy Studies: The deuterium atoms provide distinct signals, aiding in structural elucidation and dynamic studies of molecular interactions without signal interference from protons.
• Stable Isotope Labeling in Chemical Synthesis: Used as a building block in the synthesis of more complex labeled compounds for research purposes.

Basic Information

Product Name	2-Methyl-D3-Succinic-2,3,3-D3 Acid
CAS No.	347840-08-8
Molecular Formula	C5H3D3O4
Molecular Weight	135.12 g/mol (for C5H3D3O4)
Synonyms	2-Methylsuccinic-2,3,3-d3 Acid; (2R/S)-2-Methylbutanedioic-2,3,3-d3 Acid; Deuterated 2-Methylsuccinic Acid; 2-Methyl[2,3,3-2H3]succinic Acid; 2,3,3-Dideutero-2-(trideuteriomethyl)butanedioic Acid; Methyl-D3-succinic-2,3,3-D3 Acid; Isotopically Labeled 2-Methylsuccinic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-D3-Succinic-2,3,3-D3 Acid is produced and analyzed under strict quality protocols to ensure the highest standards of isotopic and chemical purity, which are paramount for research integrity. Our quality assurance includes comprehensive testing for isotopic enrichment (D-content), chemical purity, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay by NMR or HPLC, isotopic purity by MS, and specific tests for residual solvents and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR / NMR)	Conforms to structure
Assay (HPLC / Titration)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.