Description

Sodium Butyrate-4,4,4-D3 is a stable isotope-labeled derivative of sodium butyrate, where three hydrogen atoms are replaced by deuterium at the terminal methyl group. This high-purity labeled compound is essential for precise analytical and metabolic research, providing a critical internal standard for mass spectrometry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for advanced studies in metabolism, pharmacokinetics, and biomarker discovery.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical reference standard in LC-MS and GC-MS for the accurate quantification of butyrate and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in stable isotope labeling studies to investigate short-chain fatty acid metabolism, gut microbiome function, and energy homeostasis.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of butyrate-based drug candidates and prodrugs.
• Nutritional and Biomedical Research: Facilitates research into the role of butyrate in inflammation, epigenetics, and cellular signaling by enabling precise measurement in cell cultures and in vivo models.
• Diagnostic Assay Development: Utilized in the calibration and validation of clinical diagnostic kits targeting short-chain fatty acid profiles.

Basic Information

Product Name	Sodium Butyrate-4,4,4-D3
CAS No.	347840-05-5
Molecular Formula	C4H4D3NaO2
Molecular Weight	115.10 g/mol (approx.)
Synonyms	Butyric-4,4,4-d3 Acid Sodium Salt; Sodium Butanoate-4,4,4-d3; [2H3]-Sodium Butyrate; Deuterated Sodium Butyrate; Sodium (4,4,4-2H3)butyrate; Sodium Tri-deuterobutanoate; Sodium Butyrate-d3; 4,4,4-Trideuterobutanoic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium Butyrate-4,4,4-D3 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) are provided, detailing assay, isotopic purity, and impurity profiles. We support research and regulatory requirements with comprehensive documentation and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term stability, store under an inert atmosphere or in a desiccator to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.