Description

n-Methyl-D3-Glycine Hcl is a high-purity, isotopically labeled derivative of glycine, specifically deuterated on the methyl group. This compound is essential for advanced research and development, providing a stable, non-radioactive tracer for metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and analytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference compound in quantitative bioanalysis for accurate measurement of drug metabolites and biomarkers.
• Metabolic Pathway Tracing: Used in deuterium labeling studies to investigate biochemical pathways and mechanisms of action in vivo.
• Pharmaceutical Reference Standard: Employed for the calibration and validation of analytical methods in quality control and regulatory submissions.
• Proteomics and Peptide Research: Acts as a building block for synthesizing isotopically labeled peptides for mass spectrometry-based protein quantification.
• Stable Isotope-Labeled Compound (SIL) Synthesis: A key intermediate in the preparation of more complex deuterated molecules for research.
• NMR Spectroscopy: Useful as a deuterated standard or reagent in nuclear magnetic resonance studies.

Basic Information

Product Name	n-Methyl-D3-Glycine Hcl
CAS No.	347840-04-4
Molecular Formula	C3D3H4NO2 • HCl
Molecular Weight	141.59 g/mol
Synonyms	(Methyl-d3)glycine hydrochloride; N-(Trideuteriomethyl)glycine hydrochloride; Deuterated Sarcosine HCl; Sarcosine-d3 hydrochloride; Glycine, N-(methyl-d3)-, hydrochloride; 2-[(Trideuteriomethyl)amino]acetic acid hydrochloride; (2-Deuterio-1-deuteriooxy-2-oxido-1-oxoethyl)(trideuteriomethyl)azanium chloride
EINECS	Contact for details

Quality Control

Every batch of n-Methyl-D3-Glycine Hcl is manufactured under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and MS. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and all relevant specifications is provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.