Description

N,n-Dimethyl-D6-Glycine Hcl is a deuterated derivative of N,N-dimethylglycine hydrochloride, a compound of significant interest in advanced research and development. This isotopically labeled version is essential for applications requiring precise molecular tracking and analysis, such as metabolic studies and pharmacokinetic research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers working in the fields of drug discovery, biomarker analysis, and stable isotope labeling.

Application

• Pharmaceutical Research & Drug Development: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of N,N-dimethylglycine and related metabolites in biological matrices.
• Metabolomics and Biomarker Discovery: A critical tool in metabolic pathway analysis and flux studies to understand disease mechanisms and identify potential biomarkers.
• Pharmacokinetic (PK) and Absorption, Distribution, Metabolism, and Excretion (ADME) Studies: Enables precise tracking of drug candidates and their metabolites in vivo, providing crucial data on drug behavior and safety.
• NMR Spectroscopy: Serves as a deuterated standard or reagent in nuclear magnetic resonance (NMR) spectroscopy to simplify spectra and aid in structural elucidation.
• Synthesis of Labeled Compounds: Acts as a building block for the synthesis of more complex deuterated molecules for specialized research applications.
• Nutritional and Dietary Supplement Research: Employed in studies investigating the role of dimethylglycine (DMG) and its metabolic effects.

Basic Information

Product Name	N,n-Dimethyl-D6-Glycine Hcl
CAS No.	347840-03-3
Molecular Formula	C4D6H3NO2 • HCl
Molecular Weight	152.62 g/mol (for C4D6H3NO2 • HCl)
Synonyms	N,N-Dimethyl-d6-glycine hydrochloride; (Dimethyl-d6)aminoacetic acid hydrochloride; Deuterated DMG HCl; N,N-Dimethylglycine-d6 hydrochloride; (Carboxymethyl)dimethyl-d6-ammonium chloride; 2-[(Dimethyl-d6)amino]acetic acid hydrochloride; DMG-d6 HCl; Sarosine-d6 hydrochloride
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-D6-Glycine Hcl is produced under strict quality management protocols to ensure high isotopic purity and chemical integrity, critical for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., D-atom %), assay, and impurity profile is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuteration pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS or NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.