Description

(2S,5S)-(-)-2-tert-Butyl-3-Methyl-5-Benzyl-4-Imidazolidinone is a high-value chiral imidazolidinone derivative, widely recognized as a privileged organocatalyst in asymmetric synthesis. Its core value lies in enabling highly enantioselective transformations, which are critical for producing single-enantiomer pharmaceuticals and fine chemicals with superior purity and efficacy. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts for complex synthetic routes.

Application

• Asymmetric Organocatalysis: Serving as a key catalyst for enantioselective aldol, Mannich, Diels-Alder, and Michael addition reactions.
• Pharmaceutical Intermediate Synthesis: Facilitating the production of chiral active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Development: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A fundamental tool in methodological development for new asymmetric synthetic protocols.
• Fine Chemical Production: Enabling the manufacture of chiral flavors, fragrances, and advanced material precursors.
• Process Chemistry Optimization: Implementing scalable, metal-free catalytic processes for greener and more cost-effective manufacturing.

Basic Information

Product Name	(2S,5S)-(-)-2-tert-Butyl-3-Methyl-5-Benzyl-4-Imidazolidinone
CAS No.	346440-54-8
Molecular Formula	C₁₅H₂₂N₂O
Molecular Weight	246.35 g/mol
Synonyms	(2S,5S)-2-tert-Butyl-3-methyl-5-benzylimidazolidin-4-one; (S,S)-tert-Butylmethylbenzylimidazolidinone; MacMillan Catalyst (first generation derivative); (2S,5S)-(-)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone; (S,S)-2-tert-Butyl-3-methyl-5-benzylimidazolidin-4-one; (S,S)-t-Bu-Me-Bn-imidazolidinone; Organocatalyst I; Chiral Imidazolidinone Catalyst
EINECS	Contact for details

Quality Control

Our (2S,5S)-(-)-2-tert-Butyl-3-Methyl-5-Benzyl-4-Imidazolidinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic performance. We employ advanced analytical techniques, including chiral HPLC, NMR, and MS, to verify chemical identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.