Description

2-(Propyl-2,2-D2)Pentanoic-4,4-D2 Acid CAS NO 345909-03-7 is a deuterium-labeled analog of 2-propylpentanoic acid, a compound of significant interest in advanced research and development. This high-purity, isotopically enriched material serves as a critical internal standard and tracer, enabling precise quantification and detailed metabolic pathway analysis in complex biological matrices. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for quantitative bioanalysis using LC-MS/MS and GC-MS, ensuring accuracy and reproducibility in pharmacokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a stable isotope-labeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates.
• Forensic and Clinical Toxicology: Employed in the precise detection and quantification of valproic acid and related compounds in biological samples for diagnostic and legal purposes.
• Metabolomics Research: Facilitates the tracking and identification of metabolic pathways and flux analysis in systems biology studies.
• Reference Material for NMR Spectroscopy: Serves as a deuterated standard in nuclear magnetic resonance (NMR) spectroscopy for method validation and structural elucidation.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradants during drug development and quality control.

Basic Information

Item	Details
Product Name	2-(Propyl-2,2-D2)Pentanoic-4,4-D2 Acid
CAS No.	345909-03-7
Molecular Formula	C8H12D4O2
Molecular Weight	148.25 g/mol (approx.)
Synonyms	2-Propylpentanoic-2,2,4,4-d4 Acid; Deuterated Valproic Acid (d4); 2-Propyl-d4-valeric Acid-d4; Divalproex Acid-d4; Valproate-d4; 2-(2,2-Dideuteriopropyl)pentanoic-4,4-d2 Acid; 2-Propylpentanoic Acid-d4; [2H4]-Valproic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(Propyl-2,2-D2)Pentanoic-4,4-D2 Acid is manufactured and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR, HPLC, and MS, to ensure compliance with the stringent requirements of research and pharmaceutical standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.