Description

1-Methyl-3-Trifluoromethylpyrazole-5-Boronic Acid is a high-value organoboron building block, specifically a pyrazole boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of novel heterocyclic compounds with potential biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, herbicides, and fungicides.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes, inhibitors, and tool compounds for target validation and drug discovery programs.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 1-Methyl-3-Trifluoromethylpyrazole moiety into more complex molecules.
• Library Synthesis: Ideal for parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	1-Methyl-3-Trifluoromethylpyrazole-5-Boronic Acid
CAS No.	344591-91-9
Molecular Formula	C5H6BF3N2O2
Molecular Weight	193.92 g/mol
Synonyms	5-Borono-1-methyl-3-(trifluoromethyl)-1H-pyrazole; (1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)boronic acid; 1-Methyl-3-trifluoromethyl-1H-pyrazole-5-boronic acid; 1-Methyl-3-(trifluoromethyl)-5-pyrazoleboronic acid; 1-Methyl-3-(trifluoromethyl)pyrazole-5-boronic acid; 3-Trifluoromethyl-1-methylpyrazole-5-boronic acid; 344591-91-9
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-Trifluoromethylpyrazole-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.