Description

Dl-Histidine-Alpha,Beta,β-D3 CAS NO 344299-50-9 is a deuterium-labeled isotopologue of the amino acid histidine, specifically labeled at the alpha, beta, and beta positions. This compound is a critical tool in advanced research, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR techniques. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and academic research sectors who require stable isotope-labeled standards for accurate quantification and mechanistic investigations.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of histidine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Enables the study of amino acid metabolism, protein synthesis, and turnover in cell culture, animal models, and clinical research.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug candidates containing histidine or similar structures.
• Biomarker Research: Facilitates the discovery and validation of histidine-related biomarkers in disease states such as metabolic disorders and cancer.
• NMR Spectroscopy: Serves as a probe in nuclear magnetic resonance studies to elucidate molecular structure, dynamics, and interactions without signal interference from protons.
• Nutritional and Clinical Research: Applied in studies investigating protein digestion, amino acid absorption, and nutritional status assessment.

Basic Information

Product Name	Dl-Histidine-Alpha,Beta,β-D3
CAS No.	344299-50-9
Molecular Formula	C6H6D3N3O2
Molecular Weight	158.17 g/mol
Synonyms	DL-Histidine-α,β,β-d3; (RS)-Histidine-2,3,3-d3; Histidine-d3 (alpha,beta,beta labeled); 2-Amino-3-(1H-imidazol-4-yl)propanoic-2,3,3-d3 acid; (±)-Histidine-α,β,β-d3; Histidine (alpha,beta,β-d3) racemic; L-Histidine-2,3,3-d3 (racemic); Amino acid-d3 internal standard
EINECS	Contact for details

Quality Control

Our Dl-Histidine-Alpha,Beta,β-D3 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and batch-to-batch consistency suitable for sensitive research applications. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity (atom % D), chemical purity (by HPLC), and identification. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (atom % D)	≥ 98.0% (by MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.