Description

Histamine-Alpha,Alpha,Beta,β-D4 2HCl is a deuterium-labeled isotopologue of histamine dihydrochloride, a critical biogenic amine. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and precision in analytical workflows. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for method development and validation.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of histamine in complex biological matrices such as plasma, serum, and tissue homogenates.
• Metabolomics and Biomarker Research: Enables precise tracking and measurement of histamine and its metabolites in studies of allergic response, inflammation, and neurological function.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies of antihistamine drugs and related therapeutics.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity assays for diagnosing mast cell activation disorders and other histamine-related pathologies.
• Food Safety and Quality Control: Applied in methods to detect and quantify histamine in food products, crucial for preventing scombroid fish poisoning.
• Reference Material: Serves as a high-purity certified reference material (CRM) for instrument calibration and ensuring regulatory compliance in analytical testing.

Basic Information

Item	Detail
Product Name	Histamine-Alpha,Alpha,Beta,β-D4 2HCl
CAS No.	344299-48-5
Molecular Formula	C5H5D4N3 • 2HCl
Molecular Weight	207.12 g/mol
Synonyms	Histamine-d4 Dihydrochloride; [2,2,4,4-2H4]Histamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethanamine-α,α,β,β-d4 Dihydrochloride; 4-(2-Aminoethyl)imidazole-α,α,β,β-d4 Dihydrochloride; Histamine-(α,α,β,β-d4) 2HCl; Deuterated Histamine 2HCl; Histamine Internal Standard-d4; Histamine-d4 (2HCl)
EINECS	Contact for details

Quality Control

Our Histamine-Alpha,Alpha,Beta,β-D4 2HCl is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We ensure compliance with relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.