Description

3,4,5-Trimethoxyphenylacetic-2,2-D2 Acid CAS NO 344299-45-2 is a deuterated derivative of 3,4,5-trimethoxyphenylacetic acid, where two hydrogen atoms at the α-carbon position are replaced with deuterium. This isotopic labeling is critical for applications requiring enhanced analytical precision, metabolic stability, and mechanistic studies. It serves as a key synthetic intermediate and reference standard for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Used in the synthesis of deuterated drug candidates and active pharmaceutical ingredients (APIs) to study pharmacokinetics and metabolic pathways.
• Analytical Reference Standard: Serves as a high-purity internal standard for quantitative analysis via LC-MS, GC-MS, and NMR in bioanalytical and forensic laboratories.
• Metabolic Research: Employed as a tracer in drug metabolism and disposition (DMPK) studies to investigate isotope effects and metabolic stability.
• Agrochemical Development: Acts as a building block for creating novel, labeled agrochemicals and studying their environmental fate.
• Chemical Biology Probes: Utilized in the development of isotopic probes for mechanistic enzymology and protein interaction studies.
• Material Science Research: Investigated for potential use in organic electronics and advanced polymers where isotopic purity can influence material properties.

Basic Information

Product Name	3,4,5-Trimethoxyphenylacetic-2,2-D2 Acid
CAS No.	344299-45-2
Molecular Formula	C11H12D2O5
Molecular Weight	214.23 g/mol
Synonyms	3,4,5-Trimethoxybenzeneacetic-2,2-d2 Acid; (3,4,5-Trimethoxyphenyl)acetic-2,2-d2 Acid; 2,2-Dideutero-2-(3,4,5-trimethoxyphenyl)acetic Acid; 3,4,5-Trimethoxyphenyl-d4-acetic Acid (common misnomer); TMOPA-d2; Deuterated TMOPA; 344299-45-2; α,α-Dideutero-3,4,5-trimethoxyphenylacetic Acid
EINECS	Contact for details

Quality Control

Our 3,4,5-Trimethoxyphenylacetic-2,2-D2 Acid is manufactured under strict quality control protocols to ensure high isotopic and chemical purity for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR or MS), and identification. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.