Description

Sodium R-3-Hydroxybutyrate-D4 CAS NO 344298-82-4 is a high-purity, deuterium-labeled sodium salt of the endogenous ketone body (R)-3-hydroxybutyrate. This stable isotope-labeled compound is essential for precise analytical quantification and metabolic pathway tracing in advanced research. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories specializing in metabolomics, pharmacokinetics, and metabolic disorder studies.

Application

• Internal Standard for LC-MS/MS and GC-MS Analysis: Serves as a critical quantitative reference standard for accurately measuring endogenous (R)-3-hydroxybutyrate levels in biological matrices like plasma, serum, and urine.
• Metabolic Flux Analysis (MFA): Used as a tracer to elucidate the dynamics of ketone body metabolism, fatty acid oxidation, and energy homeostasis in cell cultures, tissues, or whole organisms.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug effects on ketogenesis and ketolysis in preclinical and clinical research for metabolic diseases.
• Diagnostic Assay Development: Employed in the calibration and validation of high-sensitivity clinical diagnostic assays for conditions like diabetic ketoacidosis (DKA) or ketogenic diet monitoring.
• Nutritional and Sports Science Research: Facilitates the study of ketone body utilization during fasting, prolonged exercise, or nutritional ketosis.
• Stable Isotope-Labeled Reference Material: Provides a certified reference material for quality control and method validation in regulatory-compliant bioanalytical laboratories.

Basic Information

Product Name	Sodium R-3-Hydroxybutyrate-D4
CAS No.	344298-82-4
Molecular Formula	C4H3D4NaO3
Molecular Weight	130.12 g/mol (for D4 isotopologue)
Synonyms	Sodium (R)-3-Hydroxybutyrate-3,4,4,4-d4; (R)-3-Hydroxybutyric-3,4,4,4-d4 Acid Sodium Salt; Sodium (R)-3-Hydroxy[3,4,4,4-2H4]butyrate; BHB-d4 Sodium Salt; (R)-3-Hydroxybutyrate-d4 Na Salt; Deuterated Sodium β-Hydroxybutyrate; Sodium (R)-β-Hydroxybutyrate-d4
EINECS	Contact for details

Quality Control

Our Sodium R-3-Hydroxybutyrate-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity, chemical purity, and identity. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity (typically >95%), and residual solvent levels, supporting compliance with ISO 17025 and GMP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to ensure stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity	≥98 atom % D (by 1H-NMR/MS)
Chemical Purity (HPLC)	≥95%
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.