Description

5-[3-(Trifluoromethyl)Phenyl]-2-Pyrimidinylhydrosulfide is a specialized organosulfur compound featuring a pyrimidine core substituted with a trifluoromethylphenyl group. This molecular architecture makes it a valuable advanced intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical sectors for constructing novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized ligands or monomers in the development of specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in academic and industrial research to create molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	5-[3-(Trifluoromethyl)Phenyl]-2-Pyrimidinylhydrosulfide
CAS No.	344282-81-1
Molecular Formula	C11H8F3N2S
Molecular Weight	257.26 g/mol
Synonyms	5-[3-(Trifluoromethyl)phenyl]-2-pyrimidinethiol; 2-Mercapto-5-[3-(trifluoromethyl)phenyl]pyrimidine; 5-(3-Trifluoromethylphenyl)pyrimidine-2-thiol; 2-Pyrimidinethiol, 5-[3-(trifluoromethyl)phenyl]-; 344282-81-1; 5-(3-(Trifluoromethyl)phenyl)pyrimidine-2-thiol
EINECS	Contact for details

Quality Control

Our production of 5-[3-(Trifluoromethyl)Phenyl]-2-Pyrimidinylhydrosulfide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets exacting research and commercial-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes for your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.