Description

4-Bromophenyl-D4 Methyl Ketone is a deuterated isotopologue of 4-bromoacetophenone, a valuable building block in synthetic organic chemistry. This compound matters for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability in complex matrices. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for drug metabolism studies, pharmacokinetics, and the development of novel deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC/MS & GC/MS: Serves as a critical, non-interfering reference standard for the precise quantification of its non-deuterated counterpart or related metabolites in bioanalytical assays.
• Pharmaceutical Research: Used in the synthesis of deuterium-labeled drug candidates for metabolism and pharmacokinetics (DMPK) studies, leveraging the kinetic isotope effect.
• Metabolite Identification & Tracing: Facilitates the tracking and identification of drug metabolites in in vitro and in vivo studies due to its distinct mass signature.
• Agrochemical Development: Employed in the research and analysis of deuterated pesticides or herbicides to study environmental fate and degradation pathways.
• Chemical Synthesis Intermediate: Acts as a specialized precursor for the preparation of more complex deuterated aromatic compounds and fine chemicals.
• Forensic & Clinical Toxicology: Enhances the accuracy of analytical methods for detecting and quantifying specific substances in forensic and clinical samples.

Basic Information

Product Name	4-Bromophenyl-D4 Methyl Ketone
CAS No.	343942-02-9
Molecular Formula	C9H5D4BrO
Molecular Weight	201.07 g/mol (approx.)
Synonyms	1-(4-Bromophenyl)-1-deuterio-2,2,2-trideuterioethanone; 4'-Bromoacetophenone-d4; p-Bromoacetophenone-d4; 1-(4-Bromophenyl)ethanone-d4; 4-Bromoacetophenone-d4; 4-Bromoacetylbenzene-d4; Acetophenone, 4'-bromo-, d4-; 4-Bromophenyl methyl ketone-d4
EINECS	Contact for details

Quality Control

Our 4-Bromophenyl-D4 Methyl Ketone is manufactured under strict quality systems to ensure high isotopic and chemical purity, critical for its use as an analytical standard. Each batch undergoes rigorous testing, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.