Description

n-Methylpiperazine-3,3,5,5-D4 CAS NO 343864-02-8 is a deuterated analog of N-methylpiperazine, where four hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This isotopic labeling is critical for applications in analytical chemistry and drug development, where it serves as an internal standard for mass spectrometry, enhancing the accuracy and reliability of quantitative analyses. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and chemical manufacturers involved in the synthesis of deuterated compounds for metabolic studies, pharmacokinetics, and advanced material science.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of N-methylpiperazine and related compounds.
• Pharmaceutical Research & Development: Employed in the synthesis of deuterated drug candidates for metabolic stability studies, pharmacokinetic (PK) profiling, and tracing metabolic pathways.
• Metabolite Identification: Aids in the identification and quantification of metabolites in biological matrices during drug discovery and development.
• NMR Spectroscopy Solvent & Reagent: Can be used as a deuterated reagent or in deuterated solvents for nuclear magnetic resonance (NMR) spectroscopy applications.
• Chemical Synthesis Intermediate: Serves as a specialized building block for synthesizing more complex deuterated molecules in organic and medicinal chemistry.
• Forensic and Environmental Analysis: Acts as a high-purity standard for trace analysis in forensic toxicology and environmental monitoring programs.

Basic Information

Item	Details
Product Name	n-Methylpiperazine-3,3,5,5-D4
CAS No.	343864-02-8
Molecular Formula	C5H8D4N2
Molecular Weight	104.18 g/mol (deuterated form)
Synonyms	1-Methylpiperazine-3,3,5,5-d4; N-Methylpiperazine-d4; Deuterated N-Methylpiperazine; Piperazine, 1-methyl-3,3,5,5-d4-; 1-Methylpiperazine-3,3,5,5-tetradeuterio; Methylpiperazine-d4; N-MP-d4
EINECS	Contact for details

Quality Control

Our n-Methylpiperazine-3,3,5,5-D4 is produced under strict quality management systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, GC-MS, and HPLC to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (GC/HPLC)	≥ 98%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.