Description

4-Acetamido-D3-Antipyrine is a deuterium-labeled analog of the pharmaceutical intermediate 4-acetamidoantipyrine. This stable isotope-labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by researchers and manufacturers in the pharmaceutical and analytical chemistry sectors for use as an internal standard in mass spectrometry, metabolic studies, and drug development.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of antipyrine and its metabolites in bioanalytical methods, ensuring high precision in pharmacokinetic studies.
• Metabolic Pathway Tracing: Employed in drug metabolism and disposition (DMPK) research to elucidate metabolic pathways and identify metabolites.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and method validation in pharmaceutical analysis.
• Deuterium-Labeled Building Block: Acts as a precursor or intermediate in the synthesis of more complex deuterated compounds for research.
• Clinical Research: Facilitates precise measurement of drug concentrations in biological matrices for clinical trial sample analysis.

Basic Information

Product Name	4-Acetamido-D3-Antipyrine
CAS No.	342821-66-3
Molecular Formula	C13H12D3N3O2
Molecular Weight	245.30 g/mol
Synonyms	4-Acetamidoantipyrine-d3; 1,5-Dimethyl-2-phenyl-4-(acetamido-d3)-3-pyrazolone; 4-(Acetylamino)-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one-d3; 4-Acetamido-1,5-dimethyl-2-phenyl-3-pyrazolone-d3; Deuterated 4-Acetamidoantipyrine; [D3]-4-Acetamidoantipyrine; Noramidopyrine Methanesulfonate Sodium Impurity D (d3)
EINECS	Contact for details

Quality Control

Our 4-Acetamido-D3-Antipyrine is manufactured under strict quality systems to ensure high chemical and isotopic purity, meeting the rigorous demands of analytical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profile. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.