Description

Morpholine-2,2,3,3,5,5,6,6-D8 CAS NO 342611-02-3 is a deuterated derivative of morpholine, where eight hydrogen atoms are replaced with deuterium, serving as a stable isotope-labeled internal standard. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and NMR spectroscopy analyses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemistry facilities working on drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of morpholine and its metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• NMR Spectroscopy Solvent & Reagent: Used as a deuterated solvent or chemical shift reference in nuclear magnetic resonance studies to eliminate interfering proton signals.
• Pharmaceutical Research: Enables accurate tracking of drug compounds and their degradation pathways in stability testing and metabolic profiling.
• Environmental and Forensic Analysis: Supports the detection and measurement of trace levels of morpholine-related compounds in environmental samples or forensic investigations.
• Chemical Synthesis Research: Acts as a labeled building block or tracer in mechanistic studies and the synthesis of novel deuterated compounds.

Basic Information

Item	Details
Product Name	Morpholine-2,2,3,3,5,5,6,6-D8
CAS No.	342611-02-3
Molecular Formula	C4D8H1NO
Molecular Weight	93.17 g/mol (deuterated form)
Synonyms	Perdeuterated Morpholine (d8); Morpholine-d8; Tetrahydro-1,4-oxazine-d8; Diethylene imidoxide-d8; 1,4-Oxazinane-d8; 2,2,3,3,5,5,6,6-Octadeuteriomorpholine; Tetrahydro-p-oxazine-d8; Deuterated Morpholine Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Morpholine-d8 is manufactured and analyzed under strict quality management systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail isotopic enrichment (D atom %), chemical purity by GC or HPLC, and confirm identity via spectroscopic methods. Our quality commitment aligns with the standards expected for high-value reference materials in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain isotopic purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to reference spectrum
Isotopic Purity (D atom %)	≥ 98% (by 1H NMR or MS)
Chemical Purity (GC / HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.