Description

4,4'-Dimethoxy-4''-Fluorotrityl Alcohol is a specialized fluorinated trityl alcohol derivative, a crucial building block in modern organic synthesis. Its core value lies in its role as a versatile protecting group reagent, particularly for the selective protection of hydroxyl groups in complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, where it facilitates the synthesis of nucleosides, nucleotides, and other sensitive intermediates under mild conditions.

Application

• Nucleoside & Nucleotide Chemistry: As a key protecting group reagent for primary and secondary hydroxyl groups during oligonucleotide and nucleoside analog synthesis.
• Solid-Phase Peptide Synthesis (SPPS): Used in the protection of serine, threonine, and tyrosine side chains, enabling complex peptide assembly.
• Carbohydrate Chemistry: Employed for the selective protection of sugar hydroxyls in the synthesis of complex oligosaccharides and glycoconjugates.
• Pharmaceutical Intermediate Manufacturing: A critical reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially antiviral and anticancer agents.
• Fine Chemical Synthesis: Utilized in academic and industrial R&D for constructing complex molecular architectures requiring orthogonal protection strategies.
• Protecting Group for Diols: Effective for the simultaneous protection of 1,2- and 1,3-diols in polyfunctional molecules.

Basic Information

Product Name	4,4'-Dimethoxy-4''-Fluorotrityl Alcohol
CAS No.	342045-55-0
Molecular Formula	C21H19FO3
Molecular Weight	338.37 g/mol
Synonyms	4''-Fluoro-4,4'-dimethoxytrityl alcohol; FDMT-OH; 4,4'-Dimethoxy-4''-fluorotriphenylmethanol; 4''-Fluoro-4,4'-bis(methoxy)trityl alcohol; (4-Fluorophenyl)bis(4-methoxyphenyl)methanol; FDMT Alcohol; 4,4'-Dimethoxy-4''-fluorotrityl alcohol; (4-Fluoro-α,α-bis(4-methoxyphenyl)benzenemethanol)
EINECS	Contact for details

Quality Control

Our 4,4'-Dimethoxy-4''-Fluorotrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our commitment to quality assurance supports compliance in cGMP and research-grade material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.